Effective USMLE preparation combines strategic planning, focused study, and active learning techniques to maximize retention and performance. Students should start by creating a structured study schedule that allocates dedicated time for content review, question practice, and self-assessment, ensuring coverage of all high-yield topics. Utilizing trusted resources such as First Aid, UWorld, Pathoma, SketchyMedical, and Anki flashcards allows for efficient learning and reinforcement of key concepts. Regular practice with exam-style questions and timed blocks helps improve test-taking skills, identify weaknesses, and build stamina for the lengthy exam. Techniques such as spaced repetition, active recall, and concept mapping enhance long-term memory retention. Additionally, maintaining healthy routines—adequate sleep, exercise, and short breaks—supports cognitive performance. By balancing focused review, consistent practice, and self-care, students can optimize their study time and approach the USMLE with confidence and efficiency.