Effective preparation for USMLE Step 3 focuses on consolidating clinical knowledge and honing decision-making skills required for independent patient care. Key strategies include a system-based review of core clinical topics combined with extensive practice of clinical case simulations to mirror real-world scenarios. High-yield resources such as UWorld Step 3 Qbank, Master the Boards USMLE Step 3, and NBME practice materials are essential for both multiple-choice questions and computer-based case simulations (CCS). Structured study schedules that alternate between content review and timed question practice help reinforce knowledge while improving test-taking speed and accuracy. Additionally, reviewing common algorithms, guidelines, and critical management principles ensures readiness for unsupervised clinical decision-making. Success in Step 3 comes from integrating comprehensive medical knowledge with practical, patient-centered problem-solving under exam conditions.