To excel in USMLE Step 2 CK, students should focus on integrating clinical knowledge with practical decision-making and patient management skills. Key strategies include mastering high-yield resources such as UWorld Step 2 CK Qbank, OnlineMedEd, and Step-Up to Medicine, which emphasize diagnostic reasoning, treatment protocols, and clinical guidelines. Structured study plans that combine system-based review with daily practice questions help reinforce concepts while simulating exam conditions. Utilizing NBME practice exams allows students to identify weak areas and track progress. Additionally, active learning techniques—like creating summary notes, concept maps, and spaced repetition flashcards—aid retention. Success in Step 2 CK relies on balancing thorough review of core clinical topics with consistent practice of case-based, exam-style questions to develop both knowledge and real-world clinical decision-making skills.