The most effective strategies for preparing for USMLE Step 1 combine a strong conceptual understanding of basic sciences with consistent practice of exam-style questions. Students should begin by building a solid foundation using high-yield review resources such as First Aid for the USMLE Step 1, Pathoma, and SketchyMedical, focusing on core principles in anatomy, physiology, biochemistry, pathology, pharmacology, and microbiology. Integrating active learning methods—like spaced repetition with Anki flashcards—helps reinforce memory retention. Equally important is practicing with UWorld question banks and NBME practice exams, which familiarize students with the exam format, highlight knowledge gaps, and improve test-taking strategies. A balanced approach involves alternating between concept review and timed question practice, ensuring students understand the underlying principles while developing the critical thinking skills required to apply knowledge effectively under exam conditions.