The USMLE comprises three sequential steps that assess a medical graduate’s progression from foundational knowledge to independent clinical practice. Step 1 evaluates mastery of basic biomedical sciences, including anatomy, physiology, biochemistry, pathology, and pharmacology, ensuring a strong understanding of the scientific principles underlying medicine. Step 2 focuses on clinical application through two components—Clinical Knowledge (CK) and, historically, Clinical Skills (CS)—testing the ability to diagnose, manage, and communicate effectively with patients in various clinical scenarios. Step 3 measures the capacity to provide safe, effective, and independent patient care, integrating medical knowledge, clinical reasoning, and decision-making in real-world settings. Collectively, the USMLE’s structure ensures a clear progression from theoretical understanding to practical, patient-centered competence.